Enterocolitis necrotizante en recién nacidos ingresados en el Servicio de Neonatología del Hospital Escuela "Carlos Roberto Huembes" en el período comprendido de Enero 2011 a Diciembre 2013

La enterocolitis necrotizante en el recién nacido presenta un amplio espectro de manifestaciones clínicas, caracterizándose principalmente por la tríada de distensión abdominal, sangramiento gastrointestinal y neumatosis intestinal. A pesar del avance en el cuidado intensivo neonatal, persiste como una enfermedad grave, que afecta habitualmente al recién nacido pretérmino, especialmente de muy bajo peso

Simplification of Morse Decompositions using Morse Set Mergers

Abstract. A common problem of vector field topology algorithms is the large number of the resulting topological features. This paper describes a method to simplify Morse decompositions by iteratively merging pairs of Morse sets that are adjacent in the Morse Connection Graph (MCG). When Morse sets A and B are merged, they are replaced by a single Morse set, that can be thought of as the union of A, B and all trajectories connecting A and B. Pairs of Morse sets to be merged can be picked based on a variety of criteria. For example, one can allow only pairs whose merger results in a topologically simple Morse set to be selected, and give preference to mergers leading to small Morse sets.

Normal life crises and insanity : mental illness contextualised

Enligt en kartläggning från 2005 utnyttjar befolkningen i Rosengård, en kulturellt heterogen stadsdel i Malmö, avsevärt mindre psykiatrisk vård i relation till uppskattade behov i jämförelse med övrig befolkning i Malmö. Med stöd av data från en intervjustudie bland folk som bor eller arbetar i stadsdelen klargjordes flera möjliga orsaker till den låga konsumtionen. Den främsta orsaken var synen på psykisk ohälsa; om ett mentalt tillstånd inte uppfattas som en sjukdom utan en normal livskris söker man inte medicinsk behandling för det. Syftet med artikeln är att illustrera hur underkonsumtion av psykiatrisk vård bland invandrare kan förklaras av ett annorlunda synsätt på psykisk ohälsa. Interventioner bör även inkludera människors socioekonomiska och psykosociala värld snarare än att enbart fokusera på deras mentala tillstånd.According to a 2005 survey, the people of Rosengård, a culturally heterogeneous borough of Malmö, Sweden, utilise considerably less mental health services in relation to their estimated needs than the rest of the city’s population. A study based on interviews with people living or working in the area revealed several possible reasons. Most important was their perception of what constitutes mental illness. If the cause of one’s disturbed mental state is viewed as a normal life crises rather than an illness, one does not seek medical treatment. The aim of this article is to illustrate how under-utilisation of mental health services by an immigrant population can be explained by their different perceptions of what constitutes mental illness. Interventions should add concerns regarding a client’s socio-economic and psychosocial needs, rather than solely follow a medical model

Heterozygous NOTCH1 Variants Cause CNS Immune Activation and Microangiopathy

NOTCH1 belongs to the NOTCH family of proteins that regulate cell fate and inflammatory responses. Somatic and germline NOTCH1 variants have been implicated in cancer, Adams-Oliver syndrome, and cardiovascular defects. We describe 7 unrelated patients grouped by the presence of leukoencephalopathy with calcifications and heterozygous de novo gain-of-function variants in NOTCH1. Immunologic profiling showed upregulated CSF IP-10, a cytokine secreted downstream of NOTCH1 signaling. Autopsy revealed extensive leukoencephalopathy and microangiopathy with vascular calcifications. This evidence implicates that heterozygous gain-of-function variants in NOTCH1 lead to a chronic central nervous system (CNS) inflammatory response resulting in a calcifying microangiopathy with leukoencephalopathy. ANN NEUROL 2022;92:895-901